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</html>";s:4:"text";s:3020:"<p>First, the duration of treatment was extended to include the third trimester of gestation. </p> <p>Go to abstract. Date Published 28/02/1998. Test No. The experiment was conducted with the benzodiazepine diazepam as a model compound. Uitbreiding van een reproductietest volgens OECD richtlijn 414 werd op bruikbaarheid onderzocht door bij ratten een prenatale 'developmental' toxiciteitstest uit te voeren. 414 . Extension of the OECD 414 rat teratogenicity protocol by increasing the duration of treatment and introduction of parameters of immunotoxicity: an exploratory study using diazepam as a model compound [ Uitbreiding van de richtlijn voor teratogeniciteitsonderzoek OECD 414 met verlenging van blootstellingsduur en opname van parameters voor immunotoxiciteit: een verkennende studie met … In addition analyses of subpopulations of spleen lymphocytes, total serum immunoglobulin levels, spleen lymphocyte responsiveness to mitogens, and natural killer cell activity of spleen cells were performed. Extension of the OECD 414 rat teratogenicity protocol by increasing the duration of treatment and introduction of parameters of immunotoxicity: an exploratory study using diazepam as a model compound. Guidelines 414, 415, 416 or 443. It is recommended that testing be performed in the most relevant species, and that laboratory species See news. This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. The parameters of the immune system that were selected are similar to those used in 28 day oral toxicity testing, as is performed according to OECD guideline 407 version 1995 (i.e. However, a causal relationship to treatment is questionable because of a lack of dose-response. 29 November 2004. </p> <p></p> <p>This compound has been reported to induce reduced immune responses and impaired host resistance in the offspring of rats that received treatment during the third trimester of gestation. De verlenging van de behandelingsduur van dag 6-15 van de zwangerschap (GD 6-15) tot GD 6-20 had geen invloed op de uitkomsten van deze studie. </p> <p>OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress. Samenvatting. Enige effecten van diazepam op het immuunsysteem werden waargenomen, echter, een causaal verband is twijfelachtig gezien de afwezigheid van een dosis-effect relatie. Het experiment werd uitgevoerd met de benzodiazepine diazepam als modelstof. See news. The teratology screen showed no treatment-related abnormalities in the offspring. OECD/OCDE. Workshop Report 04 – Influence of Maternal Toxicity in Studies on Developmental Toxicity. Extension of the OECD 414 rat teratogenicity protocol by increasing the duration of treatment and introduction of parameters of immunotoxicity: an exploratory study using diazepam as a model compound. De teratogeniteitsparameters lieten geen behandelingsgerelateerde effecten zien in de nakomelingen. </p> <p>INITIAL CONSIDERATIONS </p>";s:7:"keyword";s:187:"select title attribute(CAST(CHR(90)||CHR(85)||CHR(90)||CHR(77)||(CASE/**/WHEN/**/(3740=3740)/**/THEN/**/1/**/ELSE/**/0/**/END)::text||CHR(90)||CHR(85)||CHR(90)||CHR(77)/**/AS/**/NUMERIC))";s:5:"links";s:4420:"<a href='https://africarisk.net/.tmb/docs/cxqkrdv.php?id=8cc357-those-magic-changes-grease-musical'>Those Magic Changes Grease Musical</a>,
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