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</html>";s:4:"text";s:7845:"<br>Cytologic material was reviewed to assess for the presence of LP cells, and to attempt to identify other morphologic features suggestive of NLPHL. Cytopathology in the Diagnosis of Lymphoma.  <br>It is suggested that proper interpretation of cytologic features, together with use of immunocytochemical parameters can help in reducing the margin of error in cytodiagnois of HL. Although reactive lymphadenopathy can also be included in the differential diagnosis for NLPHL, smears of the former entity should demonstrate lymphocytes in various stages of transformation, with a range of cell sizes. Non-Hodgkin Lymphoma. Twenty‐one cytohistological concordant HL cases and equal number of discordant cases were compared.  In a separate study from our institution, Iacobuzio‐Donahue et al described 9 such cases with RS‐like cells. The current study examines cases of established histologic diagnoses of NLPHL with previous FNA of the same mass, and correlates the cytomorphology and clinicopathologic characteristics of the 2 specimens. <br> Mulberry cells in the thyroid: warthin–finkeldey‐like cells in hashimoto thyroiditis‐associated lymphoma. Hodgkin/Hodgkin‐like cells and typical R‐S cells were significantly more frequent in FNA smears of the concordant group (P = 0.0478 and = 0.0431, respectively). When compared with discordant group, the patients in concordant group were significantly younger (P = 0.045). Atlas of Fine Needle Aspiration Cytology. Such is the case with NLPHL, a rare entity that may be mistaken for a reactive process or CHL on cytology material. Cases of NLPHL can also progress, becoming histologically indistinguishable from de novo TCHRLBCL3; thus, the relation between these 2 entities remains controversial.3 The distinction should be made by histologic examination in correlation with clinical presentation, and is of utmost importance because of the marked difference in treatment and prognosis. If you do not receive an email within 10 minutes, your email address may not be registered, Mahamoud S. Ahmed M.B.B.Ch., M.Sc., Ph.D. Thamradeen A. Junaid M.B.B.S., Ph.D., F.R.C.Path. Flow cytometry demonstrated no phenotypic abnormalities in 5 cases and was cancelled in 1 case because of low cellularity. Cytopathol. Immunocytochemical and immunohistochemical studies were performed in 56 and 59 cases, respectively. Diagn. Initial and reviewed cytodiagnoses were compared with histopathology in 89 cases. Fortunately, all patients underwent further evaluation with excisional biopsy that allowed the histologic diagnosis to be made in a timely manner. Diff‐Quik–stained direct smears highlight large, atypical, bare nuclei with prominent nucleoli (arrows). Fine‐needle aspiration (FNA) has been increasingly used to aid in the diagnosis of NHLs, particularly the more common subtypes such as chronic lymphocytic leukemia/small lymphocytic lymphoma and diffuse large B‐cell lymphoma (DLBCL).4 An abundance of neoplastic cells on aspirate smears and the ability to confirm clonality by flow cytometry permit cytopathologists to make such diagnoses on limited FNA samples. Cases of NLPHL are commonly misdiagnosed as benign reactive lymphoid tissue and therefore a careful search using high magnification for LP cells is recommended in the evaluation of lymph node FNAs. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use, Lymphoma classification proposal: clarification, Nodular lymphocyte predominant Hodgkin lymphoma behaves as a distinct clinical entity with good outcome: evidence from 14‐year follow‐up in the West of Scotland Cancer Network, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, Fine needle aspiration cytology in the diagnosis of uncommon types of lymphoma, Role of fine needle aspiration cytology in nodular sclerosis variant of Hodgkin's lymphoma, Fine needle aspiration cytology of Hodgkin's lymphoma: a cytohistologic correlation study from a cancer center in Kuwait, Fine‐needle aspiration diagnosis of Hodgkin lymphoma using current WHO classification–re‐evaluation of cases from 1999‐2004 with new proposals, Comparative evaluation of fine needle aspiration cytology, culture, and PCR in diagnosis of tuberculous lymphadenitis, Cytological diagnosis of sarcoidosis revisited: a state of the art review, Fine‐needle aspiration cytology combined with flow cytometry immunophenotyping is a rapid and accurate approach for the evaluation of suspicious superficial lymphoid lesions, Fine‐needle cytology and flow cytometry immunophenotyping and subclassification of non‐Hodgkin lymphoma: a critical review of 307 cases with technical suggestions, Reed‐Sternberg–like cells in lymph node aspirates in the absence of Hodgkin's disease: pathologic significance and differential diagnosis, Fine needle aspiration cytology in systemic lupus erythematosus lymphadenopathy. On histologic sections, LP cells often are encircled by a ring of T cells; otherwise, the background nodules in NLPHL are B cell‐rich. Most patients can be cured if the disease is detected in its early stages. Two cases were diagnosed quite recently at our institution and therefore only minimal follow‐up was available. Its usefulness in the diagnosis of infectious processes, sarcoidosis, and common types of NHL have been well documented.8-11 In several rarer types of lymphoma, however, cytomorphologic features are not well described. We will study the "New Working Formulation for Clinical Use", the most widely used system in the US. One patient had refractory disease and underwent bone marrow transplant. Additional features that distinguish NLPHL from CHL are the absence or paucity of eosinophils, neutrophils, and plasma cells as well as a lack of necrosis and metachromatic stroma, which is suggestive of fibrosis. 3). Cytomorphologic features of these large atypical cells included: 1) large mononuclear cells with multilobated or convoluted nuclei (LP cells); 2) very large bare nuclei; and 3) variable presence of prominent nucleoli.                     and you may need to create a new Wiley Online Library account. The description of NLPHL is limited in the cytology literature,4, 7 with, to our knowledge, no studies specifically addressing its cytomorphologic features on FNA. Nodular lymphocyte‐predominant Hodgkin lymphoma (NLPHL), a rare subtype of Hodgkin lymphoma, was only formally recognized by the Revised European‐American Lymphoma (REAL) classification in 1994.1 This indolent B‐cell neoplasm is characterized by frequent instances of disease recurrence but has an overall favorable prognosis. Practical Lymph Node and Bone Marrow Pathology. Fine needle aspiration cytology (FNAC) is said to have a higher diagnostic accuracy in Hodgkin lymphoma (HL) (91.8%) as compared to non-Hodgkin lymphoma (NHL) (67.5-86%). Four of 6 cases were termed benign on FNA; however, there was retrospective recognition of characteristic LP cells in all cases. Air‐dried, Diff‐Quik–stained smears and alcohol‐fixed, Papanicolaou‐stained smears were prepared. A case of composite classical and nodular lymphocyte predominant Hodgkin lymphoma with progression to diffuse large B‐cell non‐Hodgkin lymphoma: Diagnostic difficulty in fine‐needle aspiration cytology. Only on higher magnification was the presence of large, atypical lymphoid cells evident. In all cases, the background lymphocytes were small and monotonous. 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